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Accordingly, postbiotics should be interpreted as adjunctive nutritional strategies rather than pharmacological alternatives to GLP-1 receptor agonists, with the most plausible utility during consolidation and maintenance phases aimed at improving metabolic context and supporting long-term weight-loss sustainability ( Figure 1 Importantly, accumulating preclinical evidence indicates that certain postbiotic preparations can attenuate weight gain, reduce adiposity, and activate thermogenic pathways, including brown adipose tissue signaling, particularly in high-fat dietfed rodent models

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Dont get me wrong - those trial results are spectacular (at least in patients with diabetes)

Effect of SGLT-2 inhibitors on cardiac autonomic function in type 2 diabetes mellitus: a meta-analysis of randomized controlled trials

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